Lang Wu, PhD

Lang Wu, PhD

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Full Member, Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaiʻi Cancer Center

Academic Appointment(s):
Assistant Professor, Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaiʻi Cancer Center, University of Hawaiʻi at Mānoa

Degree(s):
PhD, Clinical and Translational Science, Mayo Clinic College of Medicine
Postdoctoral Fellow, Cancer and Molecular Epidemiology, Vanderbilt University Medical Center

Research Focus

Dr. Wu’s research involves the epidemiologic investigation of genetic, molecular, nutritional, and lifestyle factors in cancer etiology and prognosis. His long-term research goal is to translate the gained knowledge for prevention, risk assessment, early detection, and prognosis prediction of human malignancies, especially for prostate and pancreatic cancer. He has been supported by a NCI K99/R00 Pathway to Independence Award to study roles of polyunsaturated fatty acids in pancreatic cancer etiology.

Currently, a main focus of Dr. Wu’s research is to conduct integrative multi-omics (genomics, transcriptomics, methylomics, proteomics & metabolomics) studies to identify novel cancer susceptibility genes and biomarkers. He has led two large transcriptome-wide association studies evaluating associations of genetically-predicted gene expression levels with risks of breast and prostate cancers, which identified multiple novel susceptibility gene candidates for these two cancers. He is also investigating DNA methylation, protein, and metabolite biomarkers associated with human cancers using genetic instruments.

Selected Publications

Wu L, Shu X, Bao J, Guo X, the PRACTICAL, CRUK, BPC3, CAPS, PEGASUS consortia, Kote-Jarai Z, Haiman CA, Eeles RA, Zheng W. (2019). Analysis of over 140,000 European descendants identifies genetically-predicted blood protein biomarkers associated with prostate cancer risk. Cancer Res, Sep;79(18):4592-4598. PMID: 31337649. PMCID: PMC6744971.

Yang Y, Wu L, Shu XO, Cai Q, Shu X, Li B et al. (2019). Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228,951 women of European descent. J Natl Cancer Inst. PMID: 31143935.

Wu L, Wang J, Cai Q, Cavazos TB, Emami NC, Long J, Shu XO, Lu Y, Guo X, Bauer JA, Pasaniuc B, Penney KL, Freedman ML, the PRACTICAL, CRUK, BPC3, CAPS, PEGASUS consortia, Kote-Jarai Z, Witte JS, Haiman CA, Eeles RA, Zheng W. (2019). Identification of novel susceptibility loci and genes for prostate cancer risk: A transcriptome-wide association study in over 140,000 European descendants. Cancer Res, Jul;79(13):3192-3204. PMID: 31101764. PMCID: PMC6606384.

Wu L, Shi W, Long J, Guo X, Michailidou K, Beesley J, et al. (2018). A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nat Genet, Jul;50(7):968-978. PMID: 29915430. PMCID: PMC6314198.

Wu L, Zheng W, Xiang YB, Gao YT, Li HL, Cai H, Shu XO. (2018). Physical activity and pancreatic cancer risk among urban Chinese: Results from two prospective cohort studies. Cancer Epidemiol Biomarkers Prev, Apr;27(4):479-487. PMID: 29475964. PMCID: PMC5971116.

Publication list via PubMed

Active Grants

L. Wu, PI
National Cancer Institute
R00 CA218892
"Uncovering roles of polyunsaturated fatty acids in pancreatic cancer etiology"
08/01/19–07/31/22