Bruce Shiramizu, MD

Bruce Shiramizu, MD

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Full Member, Cancer Biology Program, University of Hawaiʻi Cancer Center
Clinical Member, Translational and Clinical Research, University of Hawaiʻi Cancer Center

Academic Appointment(s):
Professor, Departments of Tropical Medicine, Medical Microbiology & Pharmacology; Pediatrics; Medicine, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa

Degree(s):
MD, University of Utah, Salt Lake City, Utah
Pediatric Internship/Residency, SUNY-Children's Hospital, Buffalo, NY
Pediatric Hematology/Oncology Fellowship, National Cancer Institute, NIH

Research Focus

Research in my laboratory focuses on two main areas of cancer: 1) childhood non-Hodgkin lymphoma and HIV-associated cancers. As a clinical translational researcher, the importance of my laboratory's contributions to cancer lie in being a reference laboratory for the Children's Oncology Group international NHL treatment protocol to study minimal residual disease assessment in identifying children at risk for relapse; and in engaging with the Native Hawaiian, other Pacific Islander, and Asian communities to study anal cancer screening.

Selected Publications

Chuang E, Lim E, Milne C, Zhu X, Agsalda M, Killeen J, Miller FD, Hernandez BY, Shiramizu B. (2016) Human Papillomavirus at multiple sites associated with anal squamous intraepithelial lesions in HIV-seropositive individuals. Ann Clin Cytol Pathol 2(4): 1029

Shiramizu B, Mussolin L, Woessmann W, Klapper W. (2016) Paediatric non-Hodgkin lymphoma: perspectives in translational biology.Br J Haematol. March 24, PMID 27999921, PMC4862896

Knight TE, Knight SW, Kyono W, Thompson K, Hicks J, Shiramizu B. (2016) Peripheral primitive neuroectodermal tumor and neurofibromatosis type 1 in an adolescent male. Pediatr Blood Cancer. Feb., PMID 26828586, PMC4877260

Shiramizu B, Goldman S, Smith L, Agsalda-Garcia M, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Barth MJ, Mussolin L, Cairo MS. (2015) Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt lymphoma: A Children's Oncology Group Pilot Study Report. Br J Hem. 170(3):367-71, PMID 25858645; PMC4503484

Goldman S, Smith L, Galardy P, Perkins SL, Frazer K, Sanger W, Anderson J, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo M. (2014) Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow positive Burkitt lymphoma/leukaemia: A Children's Oncology Group Report. Br J Hem, 167(3):394-401, PMID 25066629, PMC4198418.

Publication list via PubMed

Active Grants

B. Shiramizu, PI
Office of the Director/NIH
UG1HD090879
"Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials (HIPACT)"
The goal is to provide the infrastructure for clinical trials for infants, children and adolescents in Hawaii as part of the IDeA Network
09/01/2016-8/31/2020

B. Shiramizu, Executive Program Director; Hedges, Mokuau, MPIs
NIH/NIMHD
2U54MD007584-04
"RCMI Multidisciplinary and Translational Research Infrastructure eXpansion Hawaii RMATRIX-11"
The goal of the proposed U54 RCTR grant is to assure that the RMATRIX-11 infrastructure supports the further development of the Community of (clinical and translational health disparities) Investigators.
07/01/14-06/30/19

B. Shiramizu, PI
NCI, NIH
R21CA216830
"(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals"
The goal is to understand the role of HIV in HPV-associated neoplasia in HIV-serodiscordant couples.
6/1/2017-5/31/2019

B. Shiramizu, PI
NCI, NIH
R21CA216830
NCI Diversity Supplement "(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals"
The goal is to support diversity in the work field.
Pending 3/1/2018-2/28/2019 (Submitted)

B. Shiramizu, C. Shikuma, MPIs
NIMH/NIH
R01MH102196
"Maraviroc and NeuroAIDS Pathogenesis"
The goal is to investigate the role of HIV-infection of monocytes in the development of cognitive impairment.
09/01/2013-08/31/18

B. Shiramizu, C. Shikuma, MPIs
NIMH/NIH
R01MH102196
Supplement "Maraviroc and NeuroAIDS Pathogenesis"
The goal is to investigate the role of HIV-infection of monocytes in the blood-brain-barrier.
09/01/2016-08/31/18