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University of Hawaiʻi Cancer Center researchers have identified a new, less aggressive form of mesothelioma that offers patients greater hope for survival and treatment success. Led by Michele Carbone and Haining Yang, internationally recognized leaders in mesothelioma research, the team’s findings were published in the Journal of Thoracic Oncology.
The variant, called low-grade BAP1-associated mesothelioma (L-BAM), stems from inherited mutations of the BAP1 gene and is biologically different from the aggressive, asbestos-related form of the disease. Unlike traditional mesotheliomas, which resist most therapies, L-BAM often responds well, allowing some patients to live nearly normal life spans. These patients also face higher risks of other cancers, including melanoma, kidney, breast and liver cancers, making regular screening and early detection critical.
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About the University of Hawaiʻi Cancer Center
The University of Hawaiʻi Cancer Center is dedicated to saving lives in Hawaiʻi and the Pacific, and inspiring hope by working to conquer cancer. The flagship priority is to understand and address cancer health disparities. The center strives to achieve this through research, education, patient care, and community outreach, focusing on the unique and diverse ethnic, cultural, and environmental characteristics of Hawaiʻi and the Pacific.
The UH Cancer Center is one of only 74 institutions designated by the National Cancer Institute (NCI), representing a significant mark of excellence, and is the only NCI-designated cancer center in Hawaiʻi and the Pacific. The center contributes more than $57 million to Hawaiʻi's economy through scientific research, clinical trials, and other activities.
As part of the University of Hawaiʻi at Mānoa, the UH Cancer Center operates out of facilities located in Kakaʻako. The center directly employs more than 300 faculty and staff, with an additional 200 affiliate members and cooperative agreements with organizations that are part of the Hawaiʻi Cancer Consortium. The consortium includes The Queen’s Health Systems, Hawaiʻi Pacific Health, Kuakini Medical Center, Adventist Health Castle, Hawaiʻi Medical Service Association (HMSA), and the John A. Burns School of Medicine (JABSOM), all working together with the UH Cancer Center to advance cancer research and treatment in the state.
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