Joanne Ebesu and family

A cold sore for 2 months leads to oral cancer diagnosis

April 10, 2023

Joanne Ebesu felt a cold sore on her tongue. As most do, she ignored it and expected it to clear up on its own. After two months of dealing with the discomfort, she mentioned it to her dentist at her next checkup. Her dentist recommended a biopsy from an oral surgeon.

“He called me with the unfortunate results the day after my biopsy. It was stage II oral cancer,” said Ebesu, an alumna of the University of Hawaiʻi at Mānoa John A. Burns School of Medicine (JABSOM) and current biomedical researcher at Oceanit. Ebesu is known for her work with the late Yoshitsugi Hokama, professor and scientist at JABSOM, in the development of the first field-based rapid detection test kit for ciguatera fish poisoning—an illness caused by eating fish that contain toxins.

National Oral Cancer Awareness Month

Oral and oropharynx cancers include areas of the mouth and the back of the throat. This April, in observance of National Oral Cancer Awareness Month, the UH Cancer Center joins organizations across the nation to underscore the importance of early detection, and to make oral screenings a part of your dental exam routine.

In the U.S., there are, on average, 54,000 new cases of oral cancers, accounting for about 2.8% of all new cancer cases. According to the Hawaiʻi Tumor Registry operated by the UH Cancer Center, incidence rates in Hawaiʻi were significantly higher than in the U.S. overall and were higher among Hawaiʻi women than U.S. women. Risk factors include the use of tobacco and betel (Areca) nut, alcohol consumption and oral human papillomavirus (HPV) infection.

“Oral HPV has become an increasingly important risk factor specifically for oropharyngeal cancers and is a causal agent in approximately 60–70% of these tumors,” said Brenda Hernandez, a UH Cancer Center researcher.

Clinical trial helped with cancer recovery

Within weeks of her diagnosis, Ebesu underwent surgery to remove the tumor and surrounding healthy tissue from under her tongue. The surgeon then used a skin graft taken from her arm to reconstruct the area that was removed.

While recovering from surgery and subsequent radiation, Ebesu spent much time doing research on the Oral Cancer Foundation website and at the UH Cancer Center, which led her to participate in a clinical trial that helped cancer patients and survivors recover through exercise.

“Before my diagnosis, I wasn’t really aware of the important cancer research being done at the UH Cancer Center,” she said.

Hawaiʻi Oral Cancer Walk: Increasing Awareness

Through her research, she learned about the importance of screenings to find cancer before symptoms develop. As a result, in partnership with the UH Cancer Center and the Oral Cancer Foundation, Ebesu organized the Oral Cancer Walk/Fun Run for Awareness at the Sullivan Conference Center and Kakaʻako Waterfront Park to bring awareness to the disease.

Now in its fourth year, the event was held in September and included various fun activities for families to enjoy and free oral cancer screenings were available to participants. People appreciated hearing from Naoto Ueno, MD, who opened the event, and spoke about the challenges and opportunities for cancer care in Hawaiʻi and the US-affiliated Pacific Islands.

For more information and to register, visit the event website.