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Faculty

Wen-Ming Chu, MD, PhD

Wen-Ming Chu, PhD
  • Associate Professor (Associate Researcher)
    and Affiliate Member

    Cancer Biology Program
    University of Hawaii Cancer Center

Degrees

  • MD Peking Union Medical College P. R. China

Research Focus

Dr. Chu's research is directed to understanding the molecular mechanisms and the relationship between inflammation and cancer.

By using cell lines, primary cells, and knockout or conditional knockout mice, as well as mouse models of inflammatory bowel disease (IBD), AOM/DSS-induced colitis-associated colorectal cancer (CAC), and DEN-induced hepatocellular carcinoma (HCC), Dr. Chu is elucidating a new role of IκB kinases in the pathogenic process of IBD, and the mechanisms of the implication of inhibitory guanine nucleotide-binding protein alpha Gαi subunits in the pathology of breast cancer, CAC and HCC.

Also, he is investigating the roles of nucleic acid binding proteins, including DNA-PK, HMGB1 and Toll-like receptors, in the activation of innate immunity and in promoting inflammation-associated cancer. Additionally, he is interested in investigating how the above-mentioned molecules mediate immune cell migration, which is important for activation of the immune system, and for invasion and metastasis of cancer.

Selected Publications

  • Wang Z, Dela Cruz R, Ji F, Guo S, Zhang J, Wang Y, Feng GS, Birnbaumer L, Jiang M, Chu WM. (2014). Gαi proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells. Cell Commun Signal,12:10.
  • Ma C, Muranyi M, Chu CH, Zhang J, Chu WM. (2013). Involvement of DNA-PKcs in the response to IL-6. PLoS One, 8(3).
  • Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM. (2009). Gi1 and Gi3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway. Sci Signaling, 2(68), ra17. (highlighted by Science, Faculty of 1000 Biology and Cellucidate).
  • Ivanov S, Dragoi AM, Wang X, Van Essen D, Louten J, Yap GS, Wan Y, Biron CA, Bianchi ME, Wang H, Chu WM. (2007). A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood,110:1970-81. (Highlighted by Nature Review Immunology).
  • Dragoi AM, Fu X, Ivanov S, Zhang P, Shen L, Wu D, Li GC, Chu WM. (2005). DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J, 24:779-89.

Publication list via PubMed

Active Grants

  • W.M. Chu, Principal Investigator
    R01 AI054128
    NIH
    Mechanism of activation of innate immunity by immunostimulatory DNA sequences
    2002-2015
  • W.M. Chu, Principal Investigator
    Hawaii Community Foundation (HCF)
    A novel role of Gi proteins in breast cancer
    2013-2014