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Faculty

Bruce Shiramizu, MD

Bruce Shiramizu, MD
  • Full Member
    Cancer Biology Program
    University of Hawaii Cancer Center
  • Clinical Member
    Translational and Clinical Research
    University of Hawaii Cancer Center
  • Academic Appointments

  • Professor
    Departments of Tropical Medicine, Medical Microbiology & Pharmacology; and Pediatrics Graduate faculty member, Department of Tropical Medicine, Medical Microbiology, and Pharmacology
    John A. Burns School of Medicine
  • Molecular Biosciences and Bioengineering
    University of Hawaii at Manoa

Degree

  • MD
    University of Utah
    Salt Lake City, Utah
  • Pediatric Internship/Residency
    SUNY-Children's Hospital
    Buffalo, NY
  • Pediatric Hematology/Oncology Fellowship
    National Cancer Institute, NIH

Research Focus

Research in my laboratory focuses on two main areas of cancer: 1) childhood non-Hodgkin lymphoma and HIV-associated cancers. As a clinical translational researcher, the importance of my laboratory's contributions to cancer lie in being a reference laboratory for the Children's Oncology Group international NHL treatment protocol to study minimal residual disease assessment in identifying children at risk for relapse; and in engaging with the Native Hawaiian, other Pacific Islander, and Asian communities to study anal cancer screening.

Selected Publications

  • Chuang E, Lim E, Milne C, Zhu X, Agsalda M, Killeen J, Miller FD, Hernandez BY, Shiramizu B. (2016) Human Papillomavirus at multiple sites associated with anal squamous intraepithelial lesions in HIV-seropositive individuals. Ann Clin Cytol Pathol 2(4): 1029
  • Shiramizu B, Mussolin L, Woessmann W, Klapper W. (2016) Paediatric non-Hodgkin lymphoma: perspectives in translational biology.Br J Haematol. March 24, PMID 27999921, PMC4862896
  • Knight TE, Knight SW, Kyono W, Thompson K, Hicks J, Shiramizu B. (2016) Peripheral primitive neuroectodermal tumor and neurofibromatosis type 1 in an adolescent male. Pediatr Blood Cancer. Feb., PMID 26828586, PMC4877260
  • Shiramizu B, Goldman S, Smith L, Agsalda-Garcia M, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Barth MJ, Mussolin L, Cairo MS. (2015) Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt lymphoma: A Children's Oncology Group Pilot Study Report. Br J Hem. 170(3):367-71, PMID 25858645; PMC4503484
  • Goldman S, Smith L, Galardy P, Perkins SL, Frazer K, Sanger W, Anderson J, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo M. (2014) Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow positive Burkitt lymphoma/leukaemia: A Children's Oncology Group Report. Br J Hem, 167(3):394-401, PMID 25066629, PMC4198418.

Publication list via PubMed

Active Grants

  • B. Shiramizu, PI
    Office of the Director/NIH
    UG1HD090879
    "Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials (HIPACT)"
    The goal is to provide the infrastructure 9/16-8/20for clinical trials for infants, children and adolescents in Hawaii as part of the IDeA Network
    09/01/2016-8/31/2020
  • B. Shiramizu, Executive Program Director; PIs Hedges & Mokuau
    NIH/NIMHD
    2U54MD007584-04"RCMI
    Multidisciplinary and Translational Research Infrastructure eXpansion Hawaii RMATRIX-11)"
    The goal of the proposed U54 RCTR grant is to assure that the RMATRIX-11 infrastructure supports the further development of the Community of (clinical and translational health disparities) Investigators.
    07/01/14-06/30/19
  • B. Shiramizu, PI
    NCI, NIH
    R21CA216830
    "(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals"
    The goal is to understand the role of HIV in HPV-associated neoplasia in HIV-serodiscordant couples.
    6/1/2017-5/31/2019
  • B. Shiramizu, PI
    NCI, NIH
    R21CA216830
    NCI Diversity Supplement "(PQ5) Informing anal neoplasia differences/similarities in HIV-serodiscordant individuals"
    The goal is to support diversity in the work field.
    Pending 3/1/2018-2/28/2019 (Submitted)
  • B. Shiramizu, C. Shikuma, MPIs
    NIMH/NIH
    R01MH102196"Maraviroc and NeuroAIDS Pathogenesis"
    The goal is to investigate the role of HIV-infection of monocytes in the development of cognitive impairment.
    09/01/2013-08/31/18
  • B. Shiramizu, C. Shikuma, MPIs
    NIMH/NIH
    R01MH102196
    Suplement "Maraviroc and NeuroAIDS Pathogenesis"
    The goal is to investigate the role of HIV-infection of monocytes in the blood-brain-barrier.
    09/01/2016-08/31/18
  • B. Shiramizu, PI
    St. Baldrick's Foundation
    "2017 Summer Fellowship Award"
    The goal is to support a summer research fellow to work on projects related to pediatric oncology
    06/01/17-05/31/18
  • B. Shiramizu, PI
    Thomas and Sumie McCabe Foundation
    "Raman-Enhanced Screening Protocol Expanding Cancer Testing (RESPECT): An innovative approach to detect cancer cells in spinal fluid from children with leukemia and lymphoma"
    The goal is to identify unique Raman spectra fingerprint of lymphoma cells.
    11/1/16-10/31/17