Yuan Chen, PhD
- Associate Member
Natural Products and Exerimental Therapeutics Program
University of Hawaii Cancer Center
- Professor, Beckman Research Institute and
Director, NMR Core Facility
City of Hope
- PhD, Biochemistry
New Brunswick, New Jersey
- Postdoctoral Training, Structural Biology
The Scripps Research Institute
La Jolla, CA
The long-term objective of my laboratory is to identify novel mechanisms that can be targeted for developing treatments and cures for life-threatening human diseases. My current focus is on ubiquitin-like modifications, which contribute to the development of cancer and neurodegenerative disorders when dysregulated. We have identified the SUMO-interacting motif (SIM) that mediates nearly all down-stream effects of SUMOylation. In addition, using the small ubiquitin-like modifier (SUMO) modifications as a model system, my laboratory has contributed significantly to the understanding of the catalytic mechanisms of the conjugation and deconjugation enzymes. Drawing upon collaborative relationships, I have expanded my research program to encompass developing small molecule chemical probes that target the conjugation and deconjugation enzymes involved in Ubl modifications and other cancer therapeutic targets.
- Zhang X, Yueb P, Pagec BDG, Lia T, Zhao W, Namanja AT, Paladino D, Zhao J, Chen Y, Gunning PT, Turkson J. (2012). Orally bioavailable small-molecule Stat3 inhibitor regresses human breast and lung cancer xenografts. Proc Nat Acad Sci, 109(24):9623-8.
- Li Y, Perkins Al, Su Y, Ma Y, Colson L, Horne DA, Chen Y. (2012). Gold Nanoparticles as a Platform for Creating a Multi-valent Poly-SUMO Chain Inhibitor That Also Augments Ionizing Radiation. Proc Nat Acad Sci, 109(11):4092-7.
- Li Y, Stark J, Chen DJ, Ann DK, Chen Y. (2010). Role of SUMO:SIM-Mediated Protein-Protein Interaction in Non-Homologous End Joining. Oncogene, 17;29(24):3509-19, PMC207475.
- Wang J, Hu W, Lee B, Song J, Chen Y. (2007). The Intrinsic Affinity between E2 and the Cys Domain of E1 in Ubiquitin-Like Modifications. Mol Cell, 27(2):228-37. PMC1978417.
- Song J, Durrin LK, Wilkinson TA, Krontiris TG, Chen Y. (2004). Identification of a SUMO Binding Motif that Recognizes SUMO Modified Proteins. Proc Nat Acad Sci, 101(40):14373-78.
Publication list via PubMed
- Y. Chen, Co-Investigator; J. Turkson, PI
"Salicylic acid-based small-molecule Stat3 inhibitors for anticancer therapy"
The overall goal is to conduct NMR based structural studies on Stat3 inhibitors.
- Y. Chen, PI
"SUMO modification and cancer therapy"
The overall goal of this project is to investigate the role of SUMO modification in major oncogenesis pathways.
- Y. Chen, PI
"SENP: Conformational Dynamics and Inhibition by Small Molecules" The overall goal of this project is to investigate the role of conformational dynamics in SENP catalytic cycle.