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Guoxiang Xie, M.D.

Guoxiang Xie, M.D.
  • Full Non-Programmatically Aligned Member
    University of Hawaii Cancer Center
  • Academic Appointments

  • Assistant Specialist (Assistant Professor)
    University of Hawaii Cancer Center
    University of Hawaii at Manoa


  • MS (Applied Chemistry), East China University of Science & Technology, China
  • MD (Pharmaceuticals), Shanghai Jiao Tong University, China
  • Postdoctoral Fellowship (Metabolomics), University of North Carolina at Greensboro

Research Focus

Dr. Xie joined the UH Cancer Center as an assistant specialist in the Metabolomics Shared Resource since 2013. He received his MD (Pharmaceuticals) from Shanghai Jiao Tong University, Shanghai, China in 2007. Before joining the Cancer Center, he was a research scientist in the Center for Translational Biomedical Research at the University of North Carolina at Greensboro. Dr. Xie's current research focuses on conducting comprehensive metabolomics studies to 1) identify the metabolite markers for disease diagnosis and stratification, 2) define the molecular mechanisms that link metabolic disruptions in gut microbial-host co-metabolism to metabolic disorders and gastrointestinal cancer, and 3) define the molecular mechanisms of gastrointestinal carcinogenesis and bile acid metabolism.

Selected Publications

  • Jia W, Xie GX, Jia WP. (2017). Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis. Nature Reviews Gastroenterology Hepatology. doi:10.1038/nrgastro.2017.119. Epub ahead of print.
  • Xie GX, Wang XN, Huang FJ, Zhao AH, Chen WL, Yan JY, Zhang YJ, Lei S, Ge K, Zheng XJ, Liu JJ, Su MM, Liu P, Jia W (2016). Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. International Journal of Cancer, 139(8):1764-75. PMID: 27273788.
  • Xie GX, Wang XN, Liu P, Wei RM, Chen WL, Rajani C, Hernandez BY, Alegado R, Dong B, Li D, Jia W. (2016). Distinctly altered gut microbiota in the progression of liver disease. Oncotarget. 7(15):19355-66. PMID: 27036035; PMCID: PMC4991388.
  • Xie, GX, Wang, YX, Wang, XN, Zhao, AH, Chen, TL, Ni, Y, Wong, L, Zhang, H, Zhang, J, Liu, C, Liu, P, Jia, W. (2015). Profiling of Serum Bile Acids in a Healthy Chinese Population Using UPLC-MS/MS. Journal of Proteome Research,14 (2): 850-859. PMID: 25581415.
  • Xie GX, Zhong W, Li H, Li Q, Qiu YP, Zheng XJ, Chen HY, Zhao XQ, Zhang SC, Zhou ZX, Zeisel SH, Jia W. (2013). Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB Journal, 27(9):3583-93. PMID: 23709616.

Publication list via PubMed

Active Grants

  • Guoxiang Xie, Co-Investigator; W. Jia, PI
    "Gut microbiota mediated bile acid alterations in hepatic carcinogenesis"
    08/01/15 - 07/31/20