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Faculty

Daniela Gündisch, PhD

Daniela Gündisch, PhD
  • Assistant Professor
    Natural Products and Experimental Therapeutics Program
    University of Hawaii Cancer Center
  • Assistant Professor
    Department of Pharmaceutical Sciences
    University of Hawaii at Hilo

Degrees

  • PhD, Biochemistry
    University of Tübigen, Germany
  • Postdoctoral Fellow with Edythe London
    NIH/NIDA, Brain Imaging Center, Baltimore, MD
  • Habilitation, Pharmaceutical Chemistry/Medicinal Chemisty
    University of Bonn, Germany

Research Focus

Dr. Gundisch and colleagues are developing novel ligands for ion channels with one emphasis on nicotinic acetylcholine receptors (nAChRs) (design, synthesis and structure-activity relationship studies (SAR)) as potential therapeutics or as diagnostic tools for in vivo imaging (PET, SPECT). They have used natural products as structural templates or as starting material in our synthesis projects. For example, in their cytisine-based project they have developed a novel compound, which has been shown to be a partial agonist with subtype selectivity for α4/β2* nAChRs and antidepressant activity in collaboration with Marina Picciotto (Yale University) and Roger Papke (University of Florida).

Selected Publications

  • JPET, 2009, 329, 377-386
  • Synapse, 2005, 55, 89-97
  • BMC, 2004, 12, 4953-4962
  • J Med Chem, 2002, 45, 1064-1072
  • Life Sci, 2000, 67, 463-469
  • Mol Pharmacol, 2000, 57, 642-649

Publication list via PubMed

Active Grants

  • University of Hawaii Hilo Research Council
    IDeA Networks of Biomedical Research Excellence (INBRE), NIH