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Aaron Jacobs, PhD

Aaron Jacobs, PhD
  • Assistant Professor
    Cancer Biology Program
    University of Hawaii Cancer Center
  • Assistant Professor
    Department of Pharmaceutical Sciences
    University of Hawaii at Hilo


  • PhD, Pharmacology
    University of California, Los Angeles
  • Postdoctoral Fellow
    Vanderbilt University

Research Focus

Dr. Jacobs studies the activation of cellular stress responses and their effects on viability and function in relation to disease processes. A wide variety of reactive compounds, including antineoplastic drugs; xenobiotics; and endogenous metabolites are capable of inducing large-scale adaptive responses at the cellular level. One aspect of his current research examines the role of electrophilic metabolites in the activation of the heat shock response. This response is regulated by the activation of heat shock factor-1, which then drives the expression of numerous genes. Currently, his laboratory is investigating the role of specific heat shock-induced genes in tumor cell growth and viability. His work also examines stress-mediated gene expression in neurons.

Selected Publications

  • Accounts of Chemical Research, 2010, 43(5):673-683
  • Journal of Biological Chemistry, 2009, 284(14):9176-9183
  • Chemical Research in Toxicology, 2008, 21(2):432-444
  • Journal of Biological Chemistry, 2007, 282(46):33412-33420
  • Chemical Research in Toxicology, 2007, 20(7):983-985

Publication list via PubMed

Active Grants

  • Aaron Jacobs, Principal Investigator
    Research Corporation of the University of Hawaii (RCUH) Seed Grant RCUH
    "Hyperthermia-mediated c-myc turnover as a potential target in cancer therapy"
  • Aaron Jacobs, Junior Investigator; Robert Nichols, Principal Investigator
    P20 Project Grant, Hawaii IDeA Networks of Biomedical Research Excellence (INBRE)-III Hawaii Statewide Research and Education Partnership (HISREP)
    National Institute of General Medical Sciences (NIGMS)
    "Role of c-myc in the tumor promoting actions of oxidized lipids in the colon"