University of Hawai‘i at Manoa Homepage

Faculty

Lynne R. Wilkens, DrPH, MS

Lynne R. Wilkens, DrPH, MS
  • Full Member
    Population Sciences in the Pacific Program (Cancer Epidemiology)
    University of Hawaii Cancer Center
  • Director
    Biostatistics Shared Resource
    University of Hawaii Cancer Center
  • Academic Appointments

  • Specialist (Professor)
    University of Hawaii Cancer Center
    University of Hawaii at Manoa

Degrees

  • DrPH, MS, Biostatistics
    University of North Carolina at Chapel Hill

Research Focus

Dr. Wilkens has a DrPH from the University of North Carolina in Biostatistics and has worked in health research for over 30 years including over 25 years in cancer research. Much of this effort has focused on prevention in the domains of epidemiology and intervention research. A primary focus for Dr. Wilkens at UHCC has been in the quantification of cancer incidence and mortality rates for the multiethnic populations of Hawaii and the US affiliated Pacific, and studying the underlying causes of differences in cancer risks between ethnic groups. Genetic as well as lifestyle factors, including diet, physical activity, smoking and neighborhood environment, have been considered. Dr. Wilkens has published over 300 publications from these efforts.

Dr. Wilkens was one of the original biostatisticians and is currently a Multiple Principal Investigator for the Multiethnic Cohort (MEC) study (U01 CA164973). The MEC was initiated in 1993 and has followed over 215,000 individuals from 5 major ethnic groups in Hawaii and southern California for cancer and other diseases. Dr. Wilkens has vast experience with study design, data structure and data analysis for the MEC and its substudies. Dr. Wilkens leads the Data Management and Analysis Core for the P01 MEC Adiposity Phenotype study (P01 CA168530) that examines the role of body composition in cancer incidence.

Dr. Wilkens has worked in the broader Pacific. Research in the NCI-funded U54 UHCC – University of Guam Partnership (U54 CA143727) has focused on the quantification of cancer risk among ethnic groups in Guam and the role of modifiable factors, such as screening, diet and betel nut use, in cancer risk. The USDA-funded Children's Health Living Program (CHL) in the Pacific (NIFA 2011-68001-30335) quantified the prevalence of obesity in children in the US-affiliated Pacific and investigated the effect of a community-based intervention on obesity prevention.

Dr. Wilkens' primary methodological interest is in accurate measurement of exposure variables. Many of the exposures of interest to cancer are difficult to measure, such as diet and physical activity. Where possible identification of more accurate long-term biomarkers of exposure is important, such as a recently validated marker of heterocyclic aromatic amines in hair. However, there is often no preferred marker, but rather many approaches to measuring these constructs, each with unique strengths and limitations. For instance, diet can be measured through the self-reported instruments of food frequency questionnaires and dietary recalls, and through biomarkers. Biomarkers are considered less biased but generally only measure short-term exposure, and most markers do not solely reflect exposure from diet. Self-reported measures are subject to measurement error, which biases the disease association and reduces power. A better understanding of the underlying associations with disease is possible by appropriately combining data from various sources. A related topic is data integration. As high-dimensional data in various omics domains becomes increasingly available, a question arises as to how to integrate important markers from these different domains to best understand how biological processes influence disease. Newer statistical models that incorporate large sets of independent variables through constraints such as elastic net, as well as allowing for the explicit modeling of data structure, such as through a latent variable approach, hold promise to optimizing the use of data from sources with different measurement properties and scales.

Selected Publications

  • Park SY, Boushey CJ, Wilkens LR, Haiman CA, Le Marchand L. (2017). High-quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort. Gastroenterology; Apr 17. PubMed PMID: 28428143.
  • Wang H, Schmit SL, Haiman CA, Keku TO, Kato I, Palmer JR, van den Berg D, Wilkens LR, Burnett T, Conti DV, Schumacher FR, Signorello LB, Blot WJ, Zanetti KA, Harris C, Pande M, Berndt SI, Newcomb PA, West DW, Haile R, Stram DO, Figueiredo JC; Hispanic Colorectal Cancer Study, Le Marchand L. (2017). Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Int J Cancer; Jun 15;140(12):2728-2733. Epub 2017 Mar 28. PubMed PMID: 28295283.
  • Conroy SM, Clarke CA, Yang J, Shariff-Marco S, Shvetsov YB, Park SY, Albright CL, Hertz A, Monroe KR, Kolonel LN, Marchand LL, Wilkens LR, Gomez SL, Cheng I. (2017). Contextual Impact of Neighborhood Obesogenic Factors on Postmenopausal Breast Cancer: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev; Apr;26(4):480-489. Epub 2017 Jan 31. PubMed PMID: 28143808; PubMed Central PMCID: PMC5380519.
  • Setiawan VW, Wilkens LR, Lu SC, Hernandez BY, Le Marchand L, Henderson BE. (2015). Association of Coffee Intake With Reduced Incidence of Liver Cancer and Death From Chronic Liver Disease in the US Multiethnic Cohort. Gastroenterology; Jan;148(1):118-25. PMID: 25305507. PMCID: PMC4274222.
  • Park SY, Kolonel LN, Lim U, White KK, Henderson BE, Wilkens LR. (2014). Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: The Multiethnic Cohort Study. Int J Cancer; Mar 15;134(6):1504-10. PMID: 24037751. PMCID: PMC4102309.
  • Wilken[s] LR, Novotny R, Fialkowski MK, Boushey CJ, Nigg C, Paulino Y, Leon Guerrero R, Bersamin A, Vargo D, Kim J, Deenik J. (2013). Children's Healthy Living (CHL) Program for remote underserved minority populations in the Pacific region: rationale and design of a community randomized trial to prevent early childhood obesity. BMC Public Health; Oct 9;13:944. PMID: 24107083.
  • Turesky RJ, Liu L, Gu D, Yonemori KM, White KK, Wilkens LR, Le Marchand L. (2013). Biomonitoring the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in hair: impact of exposure, hair pigmentation, and cytochrome P450 1A2 phenotype. Cancer Epidemiol Biomarkers Prev; Mar;22(3):356-64. PMID: 23329727. PMCID: PMC3610405.
  • Stram DO, Hankin JH, Wilkens LR, Pike MC, Monroe KR, Park S, Henderson BE, Nomura AMY, Earle ME, Nagamine FS, Kolonel LN. (2000). Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol 2000; 151: 358-370. PMID: 10695594. PMCID: PMC4482461.
  • Kolonel LN, Henderson BE, Hankin JH, Nomura AMY, Wilkens LR, Pike MC, Stram DO, Monroe KR, Earle ME, Nagamine FS. A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol; 151: 346-357. PMID: 10695593. PMCID: PMC4482109.

Publication list via PubMed